- 4 Smith, Charles Enterprise Oil Works
- 1 Smith, Clemens Lawrence, 1844-1909
- 2 Smith, Francis, 1723-1791
- 1 Smith, Henry H. (Henry Hollingsworth), 1815-1890
- 1 Smith, Henry Porter (1797-1880)
- 1 Smith, Herbert Greenhough, 1855-1935
- 2 Smith, Horace, 1779-1849
- 2 Smith, J. Jay (John Jay), 1798-1881
- 1 Smith, James Woolen Machinery Machine Works
- 1 Smith, Kline & French Co.
- 1 Smith, O., 1786-1855
- 1 Smith, Oberlin, & Bro.
- 1 Smith, Richard Penn (playwright)
- 13 Smith, Robert, 1722-1777, Architect
- 1 Smith, Thomas Southwood, MD, 1788-1861
- 1 Smith, Wyndham (1813-1871)
- 3 Smithfield Hotel
- 1 Smithies
- 1 Smithson, Charles, 1804?-1844
- 2 Smithson, Elizabeth, 1811?-1860
- 5 Smithsonian Institution
- 1 Smithville, New Jersey
- 13 Smoke
- 1 Smokeless tobacco
- 1 Smokers
- 69 Smokestacks
- 9 Smoking
- 1 Smollett, T. (Tobias), 1721-1771
- 1 Smuggling
- 1 Smyth, James Brewery
- 16 Snails
- 32 Snakes
- 1 Snavely, C. J.
- 1 Snellenburg & Co.
- 1 Snipes
- 1 Snodgrass, Murray & Co. Cloths. (Firm)
- 66 Snow
- 2 Snow Hill Cloister
- 2 Snow removal
- 1 Snow White
