- 2 Serifs
- 1 Serle, Cecilia, 1812-1890
- 14 Serle, Thomas James, 1798-1889
- 47 Sermons
- 1 Sermons, Dutch
- 5 Servants
- 1 Servers (people, ecclesiastical)
- 535 Service books (Music)
- 1 Service Drive
- 1 Service industry facilities
- 21 Service stations
- 304 Sesqui-Centennial International Exposition
- 1 Seth (Biblical figure)
- 1 Setters' Match Works
- 8 Settlement houses
- 4 Settlements
- 1 Seven Stars Hotel
- 38 Seventeenth Street
- 3 Seventeenth Street
- 1 Seventeenth Street
- 87 Seventh Street
- 1 Seventh Street
- 27 Seventieth Street
- 1 Seventy-Eighth Street
- 2 Seventy-First Street
- 1 Sewall, Day & Co.
- 1 Seward's Laundry
- 6 Sewerage
- 7 Sewing
- 8 Sewing equipment & supplies
- 5 Sewing machine industry
- 7 Sewing machines
- 1 Seymour Street
- 1 Seymour, Horatio, 1810-1886
- 1 Seymour, Robert, 1798-1836
- 3 Shackles
- 1 Shadewall's Coverlet Manufactory
- 17 Shadows
- 1 Shadrach (Biblical figure)
- 1 Shaftesbury, Anthony Ashley Cooper, Earl of, 1801-1885
